Introduction | The Task | Resources | The Process | Learning Advice | Conclusion
Introduction- What is gene therapy ? it is an appproach to treating disease through the manipulation of an individual's genes. Currently gene therapy is being developed to treat a variety of genetic diseases and disorders as well as vacular disease, cancer, immune deficiencies, and neruodegernerative diseases. Of the 100,000 genes which comprise the human genome many have been linked to the malfunction of a single gene. Cystic fibrosis has been linked to mutations in a gene called the Cystic Fibrosis Transmembrane Regulator( CFTR) which is located on chromosome number seven. Cystic fibrosis is an autosomal recessively inherited respiratory disease resulting in the accumlation of mucus on the surface of the lungs due to the distortion of a membrane protein for the transport of the chloride ion. Patients treated by conventional methods are living longer more productive lives with advances in medicine, but still succomb to infections. Cystic fibrosis is one of the genetic diseases for which gene therapy has been developed.
You are a member of the committee which will meet to decide whether gene therapy will be initiated at your hospital,Suburbia East. In order to make the decision it will be necessary to investigate the following.
Web Quest Links
Gene Therapy. Bane or Blessing ?
Honors Genetics. Cherokee High School
Instructor- P. Sidelsky
Gene Therapy- General References
http://www.asgt.org/ - Official policy on gene therapy
http://www.mdanderson.org/depts/genetherapy/ Applications of gene therapy
http://www.stockton-press.co.uk/gt Magazine containing articles on different applications of
gene therapy. Sample Issue
http://www-ermm.cbcu.cam.ac.uk/99000691h.htm Transplantation and gene therapy reference. The reason for gene therapy in transplantation techniques is explained.
http://www3.oup.co.uk/hmg/Volume_09/Issue_09/ - Human Molecular Gene Therapy . Abstracts and articles from the magazine
http://www.rarediseases.org/ - National Organization for rare Disorders. Rare Genetic Disease dataBase
http://www.nih.gov/index.html A complete reference for gene therapy
Universities and Medical Center- Gene Therapy
http://www.bcm.tmc.edu/bmt/content_01a.html Baylor University gene therapy site. Pediatric and adult gene therapy linked to stem cells.
http://www.bcm.tmc.edu/genetherapy/links_00.html - Gene Therapy and Cancer links
http://www.bcm.tmc.edu/genetherapy/links_00.html Gene Therapy for vascular genetic diseases
http://www.med.upenn.edu/ihgt/ - Institute for Human Gene Therapy at the University of Pennsylvania. This has many links on the Jesse Gelsinger Case. Sept. 1999
http://www-ermm.cbcu.cam.ac.uk/99000691h.htm - Gene Therapy in Transplantation
http://www.mdanderson.org/patient/ On becoming a gene therapy patient
http://www.hgtri.org/main.htm - Human Gene Therapy Research Institute
Commercial Gene Therapy Products
http://www.natx.com/- Commercial site for the development of retroviral vectors
http://www.invivogen.com/- Suicide gene kits for cancer cells.
http://www.invivogen.com/- Biomedical site
http://www.wiley.co.uk/genetherapy/clinical/- Gene Therapy Clinical Trials
http://www.plasmed.com/- A diagram of a model vector in Adeno-associated virus.
http://www.ornl.gov/hgmis/publicat/hgn/v10n1/13white.html Bioethics and Gene Therapy
In Search of an Answer
1. Divide the class in groups of four students.
2. Assign each group to investigate the implementation of gene therapy in the treatment of disease from a different perspective.
a. the molecular research scientist
b. the medical team
c. the legal consultants
d. the bioethical group
e. the clinical geneticists and genetic counselors
3. Each group should prepare a presentation consisting of the following
a. Position paper
b. Audiovisual aids including an overhead ( Power Point presentation may be substituted)
c. Bibliographic references. Web sites used for reference. Any new sites discovered and described will result in additional credit.
d. All members of the group should contribute to the preparation of the final product.
Gene Investigation Tips
Information is added to the web sites in the reference section daily. Use a variety of web sites and sources to reach your opinion on the issue of gene therapy. You should include factual references for the justification of your opinion.
|Use of references|
|Total for group work|
1 - Weak. Needs additional effort. All categories deficient
2 - Below average. Some categories need additional work.
3 - Average. Meets basic requirements
4 -Shows creativity and initiative
5 -Superior in content, presentation, and preparation
This page written by Patricia L. Sidelsky
Last updated date. May 23, 2000
This page was adapted from Bernie Dodge 's WebQuest_Template1.html by Tom March